[Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation in the Development and Immune Escape of Non-small Cell Lung Cancer].
Copyright policy )[Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation in the Development and Immune Escape of Non-small Cell Lung Cancer].
Non-small cell lung cancer (NSCLC), a leading cause of cancer-related deaths worldwide, remains a significant clinical challenge despite advances in immune checkpoint inhibitors therapy, with drug resistance persisting as a major obstacle. Palmitoylation, a critical post-translational modification (PTM) primarily catalyzed by palmitoyltransferases of the zinc finger DHHC-type (ZDHHC), has recently demonstrated important implications in NSCLC. This review aims to elucidate the mechanisms and clinical potential of ZDHHC-mediated protein palmitoylation in NSCLC progression and immune escape. .
- Northwest University for Nationalities China (People's Republic of)
- China Medical University China (People's Republic of)
Lung Neoplasms, pd-l1, Lipoylation, Carcinoma, Non-Small-Cell Lung, immune escape, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Humans, Animals, zdhhc enzymes, lung neoplasms, protein palmitoylation, RC254-282, Acyltransferases
Lung Neoplasms, pd-l1, Lipoylation, Carcinoma, Non-Small-Cell Lung, immune escape, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Humans, Animals, zdhhc enzymes, lung neoplasms, protein palmitoylation, RC254-282, Acyltransferases
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