[590-S].
Copyright policy )[590-S].
590-S (1-phthalidyl-5-fluorouracil) is a derivative of 5-fluorouracil and shows a several characteristics in experimental studies. That is, good absorption from the intestine, high blood levels of 5-fluorouracil, its rapid clearance, low toxicities, excellent tumor inhibition and broad anticancer spectrum, etc. From preliminary studies and phase I studies, MTD is thought to be 750-800 mg/m2 in daily administration. Mild G.I. toxicities was encountered in a few cases. However, CNS toxicities were not experienced in any of our cases.
Adult, Male, Leukemia, Experimental, Administration, Oral, Antineoplastic Agents, Nausea, Neoplasms, Experimental, Middle Aged, Drug Administration Schedule, Anorexia, Rats, Mice, Liver Neoplasms, Experimental, Animals, Drug Evaluation, Humans, Female, Fluorouracil, Rabbits, Sarcoma, Experimental
Adult, Male, Leukemia, Experimental, Administration, Oral, Antineoplastic Agents, Nausea, Neoplasms, Experimental, Middle Aged, Drug Administration Schedule, Anorexia, Rats, Mice, Liver Neoplasms, Experimental, Animals, Drug Evaluation, Humans, Female, Fluorouracil, Rabbits, Sarcoma, Experimental
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