Skin aging is characterized by loss of elasticity, wrinkles, and textural changes. Treatments range from non-invasive options, such as alpha-hydroxy acids and retinoic acid, to invasive procedures like chemical peels and laser therapies. Plasma radiofrequency (PRF) offers a minimally invasive solution with a favorable balance of efficacy and tolerability. This study assessed the clinical and microscopic outcomes of combining PRF ablation with a galenic cream containing 5% resorcinol in NourivanTM Antiox for facial skin aging. Forty-one patients with visible signs of aging underwent a single PRF session followed by weekly applications of a 5% resorcinol cream for six weeks. Outcomes were evaluated using digital photography and line-field confocal optical coherence tomography (LC-OCT) at baseline, three months, and six months. Primary endpoints included wrinkle reduction and texture improvement; secondary endpoints included adverse effects and patient satisfaction. At six months, 92% of patients showed significant wrinkle reduction and improved collagen organization in LC-OCT images. Skin texture improvements were reported by 85% of patients. Adverse effects, such as mild erythema and peeling, were transient and resolved without discontinuation. PRF ablation combined with 5% resorcinol cream is an effective and well-tolerated treatment for facial skin aging, offering significant improvements in skin texture and appearance. Further research is needed to confirm these findings and explore long-term effects.