[Influence of anticarcinogenic agents on the transplacental carcinogenic effect of N-nitroso-N-ethylurea].

V G, Bespalov; V A, Aleksandrov

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Bulletin of Experimental Biology and Medicine

Article . 1985

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[Influence of anticarcinogenic agents on the transplacental carcinogenic effect of N-nitroso-N-ethylurea].

descriptionPublicationkeyboard_double_arrow_right Article 23 Sep 1985 Russian Journal:Biulleten' eksperimental'noi biologii i meditsiny, volume 100 (issn: 0365-9615,

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Authors: V G, Bespalov; V A, Aleksandrov;

pmid: 4016244

[Influence of anticarcinogenic agents on the transplacental carcinogenic effect of N-nitroso-N-ethylurea].

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Abstract

Experiments on rats were made to study the action of 7 anticarcinogenic substances administered postnatally for a long time (sodium selenite, retinol acetate, phenformin, amber acid, low-molecular polypeptide factors of the thymus, pineal gland, and bone marrow) on the transplacental carcinogenic effect of N-ethyl-N-nitrosourea (ENU) The polypeptide factors of the thymus and pineal gland and phenformin inhibited the development of nervous system and renal tumors induced transplacentally by ENU. The rest of the substances did not influence the transplacental carcinogenesis.

Keywords

Male, Time Factors, Placenta, Nervous System Neoplasms, Drug Evaluation, Preclinical, Antineoplastic Agents, Kidney Neoplasms, Nitrosourea Compounds, Rats, Pregnancy, Ethylnitrosourea, Prenatal Exposure Delayed Effects, Animals, Female

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