Klebsiella pneumoniae bacteria is one of the pathogens that are often found in poultry and can cause various diseases in animals and humans. Currently, there are many reports of increasing multidrug resistance (MDR) K. pneumoniae showing including carbapenems, extended spectrum beta-lactamase (ESBL), and fluoroquinolones.The purpose of this study was to determine the antibiotic resistance pattern and the presence of multidrug resistance K. pneumoniae isolates isolated from duck cloacal swabs taken from duck farms in three different sub-districts, namely Paras sub-district, Karang Turi sub-district, and Tembelang sub-district, Jombang district.This study used 180 duck cloaca swab samples and analyzed for the presence of K. pneumoniae using standard microbiology techniques. Positive isolates of K. pneumoniae were then tested for antibiotic resistance using the disk diffusion test method.This study showed that 21 (100%) isolates were resistant to antibiotics and 16 (76.19%) isolates were MDR.The presence of bacteria that are resistant to many types of antibiotics is a threat to public and animal health.