Serum pepsinogen I levels in relation to pepsinogen phenotypes.

G, Pals; I, Biemond; J, Défize; B D, Westerveld; J C, Pronk; S G, Meuwissen; A W, Eriksson

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Article . 1985

Data sources: Europe PubMed Central

Serum pepsinogen I levels in relation to pepsinogen phenotypes.

descriptionPublicationkeyboard_double_arrow_right Article 17 May 1985 English Journal:Progress in clinical and biological research, volume 173 (issn: 0361-7742,

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Authors: G, Pals; I, Biemond; J, Défize; B D, Westerveld; J C, Pronk; S G, Meuwissen; A W, Eriksson;

pmid: 3983199

Serum pepsinogen I levels in relation to pepsinogen phenotypes.

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Abstract

Serum PG I levels were measured by an enzyme linked immuno sorbent assay (ELISA) in 567 blood donors and 171 patients from a routine gastroscopy program to study the relationship between PG I phenotypes and serum levels. In normal subjects no association was found between PG I phenotypes and serum levels. A low serum PG I level in patients was associated with phenotypes characterized by intense PG I fraction 5. This probably reflects the high frequency of these phenotypes in patients with atrophic gastritis or gastric cancer. The mean (+/- SD) serum PG I level was 45.8 +/- 17.7 micrograms/1 in control subjects. Serum PG I levels were lower in females (41.4 +/- 17.5) than in males (47.3 +/- 17.7) and increased with advancing age up to 65 years.

Keywords

Adult, Male, Adolescent, Models, Genetic, Pepsinogens, Age Factors, Stomach Diseases, Enzyme-Linked Immunosorbent Assay, Middle Aged, Phenotype, Pepsinogen A, Gastroscopy, Humans, Female, Aged

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