Edwardsiella tarda, among other Enterobacteriaceae, is a rare isolate from clinical specimens in man. A liver abscess caused by E. tarda was found in a middleaged woman without overt epidemiologic exposure to known reservoirs of this organism. While the most likely source of infection was the bowel, we failed to demonstrate a gut carriage of E. tarda or to show any local condition predisposing to the development of the liver lesion.