[Aldehyde dehydrogenases in the rat liver after implantation of a prolonged-action preparation of an alcohol deterrent].

K L, Konoplitskaia; T N, Pozniakova; M V, Grigor'eva

Found an issue? Give us feedback

https://pubmed.ncbi....arrow_drop_down

https://pubmed.ncbi.nlm.nih.go...

Article . 1985

Data sources: Europe PubMed Central

[Aldehyde dehydrogenases in the rat liver after implantation of a prolonged-action preparation of an alcohol deterrent].

descriptionPublicationkeyboard_double_arrow_right Article 20 Nov 1985 Russian Journal:Voprosy meditsinskoi khimii, volume 31 (issn: 0042-8809,

Copyright policy )

Authors: K L, Konoplitskaia; T N, Pozniakova; M V, Grigor'eva;

pmid: 3901512

[Aldehyde dehydrogenases in the rat liver after implantation of a prolonged-action preparation of an alcohol deterrent].

- Summary
- Subjects
- Metrics

Abstract

Activity of aldehyde dehydrogenase isoenzymes was studied in rat liver mitochondria and microsomes after implantation of the new antialcohol drug of the long-term effect synthesized on the basis of disulphirame. Disulphirame, both in vivo and in vitro was shown to inhibit dissimilarly these isoenzymes. The degree of sensitivity of various aldehyde dehydrogenase isoenzymes to disulphirame is important for estimation of the drug efficiency.

Keywords

Drug Implants, Time Factors, Mitochondria, Liver, Rats, Isoenzymes, Alcohol Oxidoreductases, Liver, Disulfiram, Microsomes, Liver, Animals

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	3
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average