
2 boys aged 4 and 6 1/2 years and a 1 1/2-year-old girl in whom persistent EBV-infections developed are described. Serological investigations showed a markedly increased IgG-antibody titer against the virus-capsid antigen (VCA-IgG). Furthermore there was a persistence of anti-early-antigen-antibodies (anti-EA-antibodies) resp. VCA-IgA indicating a chronic infection. The observation period was 1 to 4 years. Cellular immunity in these children was depressed. They show the typical clinical symptoms of infectious mononucleosis; additionally they often suffer from other infectious diseases.
Male, B-Lymphocytes, T-Lymphocytes, Infant, Antibodies, Viral, Cell Transformation, Viral, Immunoglobulin M, Child, Preschool, Immunoglobulin G, Humans, Capsid Proteins, Female, Infectious Mononucleosis, Child, Antigens, Viral, Follow-Up Studies
Male, B-Lymphocytes, T-Lymphocytes, Infant, Antibodies, Viral, Cell Transformation, Viral, Immunoglobulin M, Child, Preschool, Immunoglobulin G, Humans, Capsid Proteins, Female, Infectious Mononucleosis, Child, Antigens, Viral, Follow-Up Studies
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