[Blood antioxidative enzymes during epileptic activity].

E V, Nikushkin; G N, Kryzhanovskiĭ; I R, Tupeev; M M, Bordiukov; S M, Iuzefova

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Bulletin of Experimental Biology and Medicine

Article . 1987

Data sources: Europe PubMed Central

[Blood antioxidative enzymes during epileptic activity].

descriptionPublicationkeyboard_double_arrow_right Article 18 May 1987 Russian Journal:Biulleten' eksperimental'noi biologii i meditsiny, volume 103 (issn: 0365-9615,

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Authors: E V, Nikushkin; G N, Kryzhanovskiĭ; I R, Tupeev; M M, Bordiukov; S M, Iuzefova;

pmid: 3828507

[Blood antioxidative enzymes during epileptic activity].

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Abstract

It has been shown that the development of generalized epileptic activity in rats led to the decrease in superoxide dismutase (SOD) activity without affecting glutathione peroxidase (GP) and glutathione reductase (GR) activity. Long-term examination of 13 patients suffering from generalized forms of epilepsy has shown an about 30% decrease in SOD and GP activity in red blood cells. It is assumed that the functional insufficiency of the antioxidative system plays an essential role in the development of lipid peroxidation disturbances during epilepsy.

Keywords

Adult, Male, Glutathione Peroxidase, Epilepsy, Superoxide Dismutase, Rats, Inbred Strains, Bemegride, Rats, Glutathione Reductase, Chronic Disease, Animals, Humans, Oxidoreductases

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