Acute effects of pirenzepin on bronchospasm.

K, Sertl; S, Meryn; W, Graninger; A, Laggner; W, Schlick; H, Rameis

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Article . 1987

Data sources: Europe PubMed Central

Acute effects of pirenzepin on bronchospasm.

descriptionPublicationkeyboard_double_arrow_right Article 03 Apr 1987 English Journal:International journal of clinical pharmacology, therapy, and toxicology, volume 24 (issn: 0174-4879,

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Authors: K, Sertl; S, Meryn; W, Graninger; A, Laggner; W, Schlick; H, Rameis;

pmid: 3818144

Acute effects of pirenzepin on bronchospasm.

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Abstract

The response to pirenzepin, a new acetylcholine receptor blocking agent, was assessed and compared to placebo in patients with reversible bronchoconstriction. A single intravenous injection of 20 mg of pirenzepin induced a significant reduction of airway resistance compared to placebo (p less than 0.05). The anticholinergic substance pirenzepin appears to be useful in the treatment of bronchospasm.

Keywords

Male, Bronchial Spasm, Airway Resistance, Humans, Female, Pirenzepine, Aged

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