If an out-of-hospital cardiac arrest (OHCA) takes longer than 15 minutes, the chances of survival are greatly reduced. With a shockable rhythm (VF/VT), there is often a treatable underlying cause, which most often can only be treated in a hospital. The patient can be transported, and circulation can be restored in the hospital, using extracorporeal cardiopulmonary resuscitation (ECPR) to gain time to treat the underlying problem. There are observational studies and one single-centre study that support the use of ECPR in refractory OHCA. However, two recent larger trials could not establish a significant benefit for ECPR. As many of these patients in refractory cardiac arrest will ultimately not survive, we will need solid cost-benefit analyses to evaluate the value of ECPR. We also need to explore the possibility of starting ECPR on scene, to reduce low-flow time even more, and hopefully improve the outcome of out-of-hospital cardiac arrest patients.