[Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases].

Kaibo, Sun; Yuangang, Wu; Yi, Zeng; Mingyang, Li; Limin, Wu; Bin, Shen

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Article . 2023

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[Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases].

descriptionPublicationkeyboard_double_arrow_right Article 23 Jun 2023Journal:Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, volume 37 (issn: 1002-1892,

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Authors: Kaibo, Sun; Yuangang, Wu; Yi, Zeng; Mingyang, Li; Limin, Wu; Bin, Shen;

pmid: 37331956

pmc: PMC10277243

[Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases].

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Abstract

To review the research progress of mitochondrial dynamics mediated by optic atrophy 1 (OPA1) in skeletal system diseases.The literatures about OPA1-mediated mitochondrial dynamics in recent years were reviewed, and the bioactive ingredients and drugs for the treatment of skeletal system diseases were summarized, which provided a new idea for the treatment of osteoarthritis.OPA1 is a key factor involved in mitochondrial dynamics and energetics and in maintaining the stability of the mitochondrial genome. Accumulating evidence indicates that OPA1-mediated mitochondrial dynamics plays an important role in the regulation of skeletal system diseases such as osteoarthritis, osteoporosis, and osteosarcoma.OPA1-mediated mitochondrial dynamics provides an important theoretical basis for the prevention and treatment of skeletal system diseases.

Related Organizations

West China Hospital of Sichuan University
China (People's Republic of)
Sichuan University
China (People's Republic of)

Keywords

Osteoarthritis, Humans, Osteoporosis, Mitochondrial Dynamics, GTP Phosphohydrolases

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