The Canadian Association of Neuropathologist - Association canadienne des neuropathologistes (CANP-ACNP) held their 61st annual meeting via Zoom from October 14th to 16th, 2021, under the leadership of Dr. Peter Gould, President of the CANP-ACNP, Dr. Peter Schutz, Secretary Treasurer of the CANP-ACNP, and with technical support from CANP administrators Heather Dow and Colleen Fifield. The academic program comprised 17 scientific abstracts, 8 unknown cases, the Presidential symposium on Epilepsy and Neoplasms, and a Neuropathology in Practice session on the implementation of the new WHO classification of CNS neoplasms in Canada. Digital pathology images from the 8 unknown cases are available for viewing online (www.canp.ca). The unknown case sessions were moderated by Dr. Andrew Gao. The Presidential Symposium 2021 on Epilepsy and Neoplasms featured the David Robertson Lecture given by Dr. Eleonora Aronica entitled Evolving classification of epilepsy-associated tumors: Understanding epileptogenesis, the Gordon Mathieson Lecture delivered by Dr. Harvey Sarnat on Why are some cerebral malformations more epileptogenic than others? Clues from developmental neuropathology, and the Jerzy Olszewsky Lecture presented by Dr. Maria Thom on Neuropathology in sudden and unexpected death in epilepsy and future directions. The program was completed Dr. George Ibrahim's lecture on Epilepsy as a network disorder. The Mary Tom Award for best clinical science presentation by a trainee went to Dr. Suzy Kosteniuk (Supervisor Dr. S. Das), and the Morrison H. Finlayson Award for best basic science presentation by a trainee was won by Dr. Nicole Schwab (Supervisor Dr. L.N. Hazrati). The following abstracts were presented at the 61st annual meeting of the Canadian Association of Neuropathologists - Association candienne des neuropathologistes (CANP-ACNP) in October 2021.