The Canadian Association of Neuropathologist - Association canadienne des neuropathologistes (CANP-ACNP) held their 62nd annual meeting at the Delta Bessborough in Saskatoon, SK from October 13th to 15th, 2022, under the leadership of Dr. Robert Hammond, President of the CANP-ACNP, Dr. Peter Schutz, Secretary Treasurer of the CANP-ACNP, and with technical support from CANP administrator, Colleen Fifield. The academic program comprised 15 scientific abstracts, 9 unknown cases, a mini-symposium on competence based medical education in neuropathology, and the Presidential symposium on Multiple Sclerosis and Immune mediated Demyelinating Disease. Digital pathology images from the 9 unknown cases are available for viewing online (www.canp.ca). The unknown case sessions were moderated by Dr. Andrew Gao. The Presidential Symposium 2022 on Multiple Sclerosis and Immune mediated Demyelinating Disease featured the Gordon Mathieson Lecture given by Dr. G. R. Wayne Moore entitled Demyelination, multiple sclerosis, and MRI and the David Robertson Lecture given by Dr. Michael Levin entitled Multiple sclerosis and future therapies. The program was completed by three invited presentations with Dr. E. Ann Yeh presenting on Pediatric multiple sclerosis and immune mediated demyelination, Dr. Tanja Kuhlmann presenting on Neuropathology of MS and stem cells and Dr. Pamela Kanellis presenting on Outlook of patients and public on MS research and treatment in Canada. The Mary Tom Award for best clinical science presentation by a trainee went to Dr. Christopher Newell (Supervisor Dr. J. Joseph), and the Morrison H. Finlayson Award for best basic science presentation by a trainee was won by Dr. Erin Stephenson (Supervisor Dr. V.W. Yong). The following abstracts were presented at the 62nd annual meeting of the Canadian Association of Neuropathologists - Association candienne des neuropathologistes (CANP-ACNP) in October 2022.