Mean residence time.

descriptionPublicationkeyboard_double_arrow_right Article 18 Aug 1986 English Journal:Methods and findings in experimental and clinical pharmacology, volume 8 (issn: 0379-0355,

Authors: D, Brockmeier; H M, von Hattingberg;

pmid: 3724305

Mean residence time.

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Abstract

The definition of mean residence time in the strict sense of mathematical statistics is deduced. It is demonstrated that the area-normalized concentration time curve is an estimate of the probability density function for residence times of drug molecules in the pharmacokinetic system, provided that the area under the concentration-time profile is proportional to the total amount eliminated from the system. Criticisms (8) on the determination of the mean residence time are refuted. The linearity of pharmacokinetic systems is defined, based on the statistical interpretation of these systems.

Keywords

Kinetics, Pharmaceutical Preparations, Humans, Models, Biological

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