A case of isolated amyloidosis of the trachea in a woman aged 46 was described. The main clinical signs of the disease were dry cough, recurring hemoptysis and hoarseness of the voice. Endoscopy showed disseminated polypoid formations in the trachea. A histological study of mucosal biopsy from these formations revealed amyloid masses deposited in the submucosal layer. An additional study brought about no data on the generalized nature of amyloid dystrophy of any other organs. The use of computed tomography to determine the type of tracheal lesion in this localization of the process was shown to be promising.