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Fibroblast Activation Protein Inhibitor Theranostics: The Case for Use in Sarcoma.

Authors: Rainer, Hamacher; Helena, Lanzafame; Ilektra A, Mavroeidi; Kim M, Pabst; Lukas, Kessler; Phyllis F, Cheung; Sebastian, Bauer; +4 Authors

Fibroblast Activation Protein Inhibitor Theranostics: The Case for Use in Sarcoma.

Abstract

The theranostic use of fibroblast activation protein inhibitors (FAPIs) is a novel approach in oncology. Sarcomas are a heterogenous group of rare malignant tumors. Prognosis remains poor in advanced/metastatic disease due to limited therapeutic options. Sarcoma frequently demonstrate high expression of fibroblast activation protein alpha on the tumor cells themselves, in contrast to other solid tumors, where it is mainly expressed on cancer-associated fibroblasts. Consequently, high in vivo uptake of FAPI in PET is observed in sarcoma. Moreover, retrospective case reports and series demonstrated feasibility of FAPI radioligand therapy with signs of tumor response.

Keywords

Positron Emission Tomography Computed Tomography, Humans, Sarcoma, Gallium Radioisotopes, Precision Medicine, Fibroblasts, Medical Oncology, Retrospective Studies

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citations
The total number of citations received by all articles of the researcher of interest.
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
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