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Chemical and Pharmaceutical Bulletin
Article . 2023 . Peer-reviewed
Full-Text: https://www.jstage.jst.go.jp/article/cpb/71/6/71_c22-00779/_pdf
Data sources: Japan Link Center
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Chemical and Pharmaceutical Bulletin
Article . 2023
Data sources: Europe PubMed Central
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Atractylodes macrocephala Rhizomes Contain Anti-inflammatory Sesquiterpenes.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2023 English Publisher:The Pharmaceutical Society of JapanJournal:Chemical & pharmaceutical bulletin, volume 71 (issn: 1347-5223, Copyright policy )
Authors: Hai, Cao Thanh; Luyen, Nguyen Thi; Giang, Do Hoang; Minh, Bui Quang; Trung, Nguyen Quang; Chinh, Pham The; Hau, Dang Viet; +1 Authors

pmid: 36948639

Atractylodes macrocephala Rhizomes Contain Anti-inflammatory Sesquiterpenes.

Abstract

Two new compounds, named eudesm-4(15),7-diene-3α,9β,11-triol (1) and eudesm-4(15),7-diene-1β,3α,9β,11-tetraol (2) together with three known sesquiterpene lactones (1S,5R,7R,10R)-secoatractylolactone (3), (1S,5R,7R,10R)-secoatractylolactone-11-O-β-D-glucopyranoside (4) atractylenolide III (5) were isolated from the rhizomes of Atractylodes macrocephala. Their structures were elucidated by using one-dimensional (1D) and 2D-NMR spectra and high resolution electrospray ionization (HR-ESI)-MS data. Compound 5 exhibited the most active anti-inflammatory activity with IC50 values of 27.5 µM in inhibiting of nitric oxide production. Compounds 1, 2, and 3 showed moderate effects while compound 4 was inactive.

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Keywords

Magnetic Resonance Spectroscopy, <i>Atractylodes macrocephala</i>, Anti-Inflammatory Agents, eudesmane, Atractylodes, atractylenolide III, secoatractylolactone, anti-inflammation, Lactones, Sesquiterpenes, Rhizome

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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