[Activity of enzymes of ethanol metabolism as a test in evaluating the effectiveness of sensitizing alcohol deterrents].

G A, Pkhakadze; K L, Konoplitskaia; T N, Pozniakova; T I, Mnyshenko; V P, Nazaretian

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Article . 1987

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[Activity of enzymes of ethanol metabolism as a test in evaluating the effectiveness of sensitizing alcohol deterrents].

descriptionPublicationkeyboard_double_arrow_right Article 05 Oct 1987 Russian Journal:Ukrainskii biokhimicheskii zhurnal (1978), volume 59 (issn: 0201-8470,

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Authors: G A, Pkhakadze; K L, Konoplitskaia; T N, Pozniakova; T I, Mnyshenko; V P, Nazaretian;

pmid: 3629726

[Activity of enzymes of ethanol metabolism as a test in evaluating the effectiveness of sensitizing alcohol deterrents].

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Abstract

A procedure is developed for determination of the efficiency of the antialcoholic drugs' action on the system of ethanol oxidation in vitro: alcohol dehydrogenase by the direct and reverse reactions and aldehyde dehydrogenase of subcellular fractions of the rat liver. This procedure is also used to determine the antialcoholic activity of a number of new compounds and to compare them with disulphiram (antabus, teturam), the known antialcoholic drug.

Keywords

Ethanol, Alcohol Dehydrogenase, Aldehyde Dehydrogenase, Rats, Liver, Disulfiram, Animals, Drug Evaluation, Disulfides, Alcohol Deterrents

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