Xenotransplantation using pigs as the transplant source has the potential to resolve the severe shortage of human organ donors. Pig production is a very well controlled process and a high sanitary status for pig products is relatively easy to achieve allowing the production of pathogen free animals (SPF). However, whereas human genome express no more active endogenous retrovirus, pigs genomes posses several full length endogenous retroviral copies (PERV), which are still active. Evidences of PERV infection of human cell lines in vitro have been provided, highlighting the potential risk of cross-species infection associated with the use of porcine tissues in human. Further works have demonstrated that PERV risks are similar to the risk associated with other gammaretroviruses particularly for the integration of the proviral genome in the host's genome with a strong affinity for CpG islands and transcription start sites. Different technical solutions for the containment of this zoonotic risk are briefly presented.