[Does high-dose intravenous vitamin C has anti-cancer activity ?]

High-dose intravenously (i.v) vitamin C in cancer patients is controversial. Numerous studies carried out on cancer cell lines and animal models demonstrated that millimolar vitamin C concentrations inhibit tumor cells viability, especially in association with chemotherapy. In cancer patients, high-dose i.v vitamin C in monotherapy does not show any anti-cancer activity. Clinical trials assessing high-dose i.v vitamin C concomitantly with chemotherapy do not conclude to reliable evidence for tumor control or overall survival benefit. Randomized double-blind trials are warranted.

Related Organizations

University Hospital of Geneva
Switzerland

Keywords

Neoplasms, Animals, Humans, Administration, Intravenous, Antineoplastic Agents, Ascorbic Acid, Vitamins

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