
The largest multicenter, double-blind trial comparing piroxicam with naproxen in the treatment of osteoarthritis has recently been conducted in Norway. More than 2,000 patients were enrolled in the 12-week study. Both drugs showed similar efficacy, and serious gastrointestinal side effects occurred in less than 1 percent of the patients taking either agent. These findings are similar to results with other nonsteroidal anti-inflammatory drugs. This study indicates that in the treatment of osteoarthritis, piroxicam is as effective as naproxen and poses no greater risk of serious gastrointestinal side effects.
Adult, Aged, 80 and over, Male, Clinical Trials as Topic, Peptic Ulcer, Gastrointestinal Diseases, Norway, Age Factors, Middle Aged, Drug Administration Schedule, Piroxicam, Random Allocation, Naproxen, Sex Factors, Double-Blind Method, Osteoarthritis, Humans, Female, Gastrointestinal Hemorrhage, Aged
Adult, Aged, 80 and over, Male, Clinical Trials as Topic, Peptic Ulcer, Gastrointestinal Diseases, Norway, Age Factors, Middle Aged, Drug Administration Schedule, Piroxicam, Random Allocation, Naproxen, Sex Factors, Double-Blind Method, Osteoarthritis, Humans, Female, Gastrointestinal Hemorrhage, Aged
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