Macrolides are antibiotics with high tolerability and wide activity spectrum both against Gram-positive and Gram-negative bacteria and other pathogenic agents: Miocamycin (MOM) belongs to this group. On this basis the antibacterial of the MOM has been proved on a sampling of hospital isolated staphylococci strains in comparison to josamicin and eriytromicin all belonging to the macrolides family and also to lincomycin and clindamicyn which have the same activity spectrum. Miocamycin compared to other antibiotics proved to be the most active against both methicillin-sensitive and methicillin-resistant strains.