GABAB Receptor Antagonism from Birth to Weaning Permanently Modifies Kiss1 Expression in the Hypothalamus and Gonads in Mice.
Copyright policy )GABAB Receptor Antagonism from Birth to Weaning Permanently Modifies Kiss1 Expression in the Hypothalamus and Gonads in Mice.
The kisspeptin gene Kiss1 is expressed in two hypothalamic areas: anteroventral periventricular nucleus/periventricular nucleus (AVPV/PeN) and arcuate nucleus (ARC), and also in gonads. Several pieces of evidence suggests that gamma-amino butyric acid B receptors (GABAB) signaling can regulate Kiss1 expression. Here, we inhibited GABAB signaling from PND2 to PND21 and evaluated the hypothalamic-pituitary-gonadal (HPG) axis. Methods: BALB/c mice were treated on postnatal days 2–21 (PND2–PND21) with CGP55845 (GABAB antagonist) and evaluated in PND21 and adulthood: gene expression (qPCR) in the hypothalamus and gonads, hormones by radioimmunoassay, gonad histochemistry (H&E), puberty onset, and estrous cycles.
Fil: Libertun, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Bizzozzero Hiriart, Marianne. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Di Giorgio, Noelia Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lux, Victoria Adela R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
- National Scientific and Technical Research Council Argentina
- University of Buenos Aires Argentina
- Experimental Medicine and Biology Institute Argentina
Male, Kisspeptins, Arcuate Nucleus of Hypothalamus, Hypothalamus, SEX STEROIDS, Weaning, GAMMA-AMINO BUTYRIC ACID, Prolactin, GABA Antagonists, Mice, https://purl.org/becyt/ford/3.1, Animals, GAMMA-AMINO BUTYRIC ACID B RECEPTORS, Female, Testosterone, https://purl.org/becyt/ford/3, Sexual Maturation, KISS1, Follicle Stimulating Hormone, Gonads, GONADOTROPINS, Progesterone, Receptors, Kisspeptin-1
Male, Kisspeptins, Arcuate Nucleus of Hypothalamus, Hypothalamus, SEX STEROIDS, Weaning, GAMMA-AMINO BUTYRIC ACID, Prolactin, GABA Antagonists, Mice, https://purl.org/becyt/ford/3.1, Animals, GAMMA-AMINO BUTYRIC ACID B RECEPTORS, Female, Testosterone, https://purl.org/becyt/ford/3, Sexual Maturation, KISS1, Follicle Stimulating Hormone, Gonads, GONADOTROPINS, Progesterone, Receptors, Kisspeptin-1
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