Experts from Society of Prosthodontics, Chinese Stomatological Association have extensively solicited opinions, and formulated a recommended application guideline after many discussions and revisions, basing on experimental research, clinical and evidence-based medical results. This guideline formulated the standard operating procedure for tooth bleaching, to guide and standardize the clinical diagnosis and treatment procedure of tooth bleaching, and to improve the clinical diagnosis and treatment level and outcome of tooth bleaching, in order to effectively reduce the clinical adverse reactions of bleaching agents and promote the clinical popularization of tooth bleaching technology.