Sepsis remains a significant cause of morbidity and mortality in newborns especially in the developing countries. Salmonellosis, a global public health problem is common in tropical countries. However Salmonella enterica serotype Paratyphi B causing neonatal sepsis is rare and the survival depends on high index of suspicion and appropriate empiric therapy. We here report a case of sepsis neonatorum due to Salmonella enterica serotype Paratyphi B in a four day old baby girl. Salmonella infections should be considered in the differential diagnosis of neonatal sepsis, especially in endemic areas.