Inhibition of the butyrylcholinesterase by ethidium bromide.

The effect of ethidium bromide (3,8-diamino-5-ethyl-6-phenyl-phenanthridinium bromide) on the activity of purified horse serum butyrylcholinesterase in vitro has been studied. Ethidium bromide is a middle reversible inhibitor with complex mixed competitive-noncompetitive inhibition kinetics. The inhibitor is bound to the anionic site of the enzyme surface.

Related Organizations

Medical Research Institute
Sri Lanka

Keywords

Kinetics, Butyrylcholinesterase, Ethidium, Animals, Cholinesterases, Cholinesterase Inhibitors, Horses

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