Bioelectrical activity of the brain was studied in 20 patients with glossalgia characterized by a most severe clinical symptomatology. Neurophysiological analysis has shown a marked imbalance of the leading neuromediator cerebral systems, namely, deficiency of ascending activating reticular effects, tense functioning of syncronizing systems, and involvement into the chain of impaired relationships of the limbic-reticular complex and inhibitory systems of the brain. It has been established that general disorganization of the activity of the cerebral mechanisms is attended by impaired control of ascending afferentation. As a result, any type of chronic stimulation of the peripheral receptors is no longer blocked when entering the central nervous system and manifests in a clinically marked syndrome of glossalgia. On the basis of clinico-physiological correlations the authors draw a conclusion that the syndrome of glossalgia should be considered as one of the links in the chain of chronic emotional stress manifestations.