Investigation of cyberchondria is still in its infancy. Preliminary research suggests that cyberchondria is likely to represent a distinct behavioral syndrome which is closely associated with health anxiety/hypochondria and extensive online searching for health information and/or digital self-tracking. The internet is characterized by anonymous, readily, convenient space-time-independent accessibility and availability of an almost unmanageable amount of information that may increase the reassurance-seeking safety behavior of individuals with heightened health anxiety. Cyberchondria also appears to be related to low self-esteem, anxiety sensitivity, intolerance of uncertainty, compulsivity and metacognitive beliefs. At present, it is unclear of whether individuals with cyberchondria suffer from extensive health-related online searching behavior only or also from other forms of internet use disorders. The link between cyberchondria and e-health literacy, defined as perceived skills at finding, evaluating, and applying online health information to health problems, is poorly recognized. At present, there are no standardized therapeutic interventions for cyberchondria available. Treatment should address the maladaptive health- or illness-related assumptions and beliefs by using existing, well established approaches for hypochondria. Furthermore, it should target the problematic internet use and enable individuals with cyberchondria to reflect their subjective e-health literacy and promote a functional use of health resources from the internet.