This review article introduces a topical multidisciplinary issue such as the atherogenic impact of oral cavity dysbiosis. Pathophysiological mechanisms and pathoimmunobiochemical aspects of the atherosclerosis initiation and atheroma destabilization are observed in this manuscript. Dysbiosis of the oral microbiome is a revolutionary and contemporary risk factor for CVD development and burdening, consequently, understanding the fundamental foundations of the pathogenesis of rearrangement of the morphofunctional constant of the myocardium will allow to exact the preferred mode of cardio- and vasoprotection, which will properly affect the functional parameters of CVD and in the long term will improve both the quality of life and the prognosis. patients of the cardiological profile.