Prurigo nodularis. Prurigo nodularis is the most severe degree of chronic prurigo. Disseminated nodules (mostly on the 4 members) are associated with skin excoriations and an intense pruritus. Whatever the etiology, prurigo nodularis is autonomous disease which is related to itch sensitization (similar to pain sensitization). The burden is high. A management with different levels is recommended and the opinion of a dermatologist is frequently required. Research gives promising therapeutic perspectives.