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Folia Biologica
Article . 1988
Data sources: Europe PubMed Central
Claim

Generation of LAK cells depends on the age of LAK cell precursor donors.

descriptionPublicationkeyboard_double_arrow_right Article 18 Aug 1988 English Journal:Folia biologica, volume 34 (issn: 0015-5500, Copyright policy )
Authors: M, Indrová; J, Bubeník;

pmid: 3260565

Generation of LAK cells depends on the age of LAK cell precursor donors.

Abstract

Age-related changes in generation of lymphokine-activated killer cells were examined in the experimental system of B10 murine effector cells activated with human recombinant interleukin 2 that were allowed to react with a panel of murine and human target cell lines. The percentage of specific 51Cr release displayed by the LAK cells derived from 6- and 12-month-old donors was consistently lower than that displayed by the 2-month-old mice. However, even the LAK cells from 12-month-old mice still showed a significant cytolytic activity.

Related Organizations
Keywords

Cytotoxicity, Immunologic, Killer Cells, Natural, Aging, Mice, Animals, Interleukin-2, Recombinant Proteins, Cell Line

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    		 2
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
gold