The authors' experience with the clinical use of an antihypoxic substnace--hexosophosphate representing the complex of tetraphosphoric glucose and fructose esters is reported. The substance was studied experimentally on 20 dogs and clinically in 126 patients with diseases of vessels, abdominal organs and the kidneys. A positive effect was gained in peroral and intravenous use of the substance both with theaim of preparative management of patients to be subjected to major surgery and postoperatively. HP, being a readily absorbed energetic substance, renders a normalizing effect on the hemodynamics, the bowel activity, improves general patients'state, that is of special value in patients whose state is aggravated by concomitant lesions.