[Research progress of relationship between vitamin K and type 2 diabetes].
Copyright policy )[Research progress of relationship between vitamin K and type 2 diabetes].
Objective: To systematically review research on the association between vitamin K and type 2 diabetes and diabetes-related biomarkers in humans, and evaluate the role of vitamin K in the prevention of type 2 diabetes. Methods: "Vitamin K", "type 2 diabetes" and related terms were searched in PubMed, EMBASE, China National Knowledge Infrastructure (CNKI) and Wanfang Med Online up to November 2018. Results: A total of 1 Chinese and 12 English articles were included. Among 6 observational studies, 5 of them showed that higher dietary vitamin K intake and plasma vitamin K level were associated with the decrease of the risk of type 2 diabetes. Among 6 clinical intervention studies, 5 of them indicated that the supplementation of vitamin K(1) or K2 could have positive influence on insulin metabolism. One Mendelian randomization study showed higher circulation vitamin K level might reduce the risk of type 2 diabetes. Conclusion: Vitamin K plays an important role in the prevention and control of type 2 diabetes, which may be related to the improvement of insulin metabolism and blood glucose level.
- Huazhong University of Science and Technology China (People's Republic of)
Blood Glucose, China, Observational Studies as Topic, Vitamin K, Diabetes Mellitus, Type 2, Dietary Supplements, Humans, Insulin
Blood Glucose, China, Observational Studies as Topic, Vitamin K, Diabetes Mellitus, Type 2, Dietary Supplements, Humans, Insulin
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