Human organ culture techniques for the detection and evaluation of genotoxic agents.

W P, Watson; R J, Smith; K R, Huckle; A S, Wright

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Article . 1989

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Human organ culture techniques for the detection and evaluation of genotoxic agents.

descriptionPublicationkeyboard_double_arrow_right Article 18 Jan 1989 English Journal:IARC scientific publications (issn: 0300-5038,

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Authors: W P, Watson; R J, Smith; K R, Huckle; A S, Wright;

pmid: 3198225

Human organ culture techniques for the detection and evaluation of genotoxic agents.

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Abstract

In order to obtain information on the genotoxic metabolism of carcinogens in human skin in vivo, model in-vitro systems have been developed to mimic in-vivo metabolism qualitatively. Direct labelling (3H and 14C) and 32P-postlabelling analyses of benzo[alpha]pyrene (BP)-DNA adducts in human skin explants, CD1 mouse explants and CD1 mouse skin in vivo have thus allowed comparisons of the genotoxic metabolism of BP in mouse and human skin.

Related Organizations

Shell (United Kingdom)
United Kingdom

Keywords

Mice, Organ Culture Techniques, Benzo(a)pyrene, Animals, Humans, Female, DNA, Phosphorus Radioisotopes, Skin

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