Pharmacological studies on anethole trithione.

Pharmacological studies on trithio-p-methoxy-phenylpropene (anethole trithione, ANTT, Felviten) were performed. ANTT at a dose of 100 mg/kg, p.o. lowered the increased serum transaminases GOT and GPT, and protected the liver from injuries caused by CCl4 in mice. In other studies in vivo, ANTT at a dose of 1000 mg/kg showed no effect on the central nervous system or the autonomic nervous system. In vitro experiments with smooth muscle preparations showed no significant effects of ANTT.

Keywords

Central Nervous System, Male, Diazepam, Anethole Trithione, Muscle Relaxation, Guinea Pigs, Blood Pressure, Anisoles, Hydrogen-Ion Concentration, Motor Activity, Autonomic Nervous System, Body Temperature, Electrolytes, Mice, Liver, Heart Rate, Animals, Female, Partial Thromboplastin Time, Gastrointestinal Motility

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