
The acetoin-synthesizing activity has been studied in the skeletal muscles, brain, liver and spleen homogenates (numbered as the activity decreases). The acetoin-synthesizing activity drastically increases in case of the acetaldehyde excess and alcohol intoxication. The acetaldehyde concentrations of above 1.10(-3) M inhibit the liver pyruvate dehydrogenase activity and increase the non-oxidative transformation of pyruvate. Acetoin is rapidly metabolized in the organism eliminating from blood 10 minutes after its injection. Acetoin is an effective precursor in the biosynthesis of lipids.
Male, Muscles, Myocardium, Acetoin, Brain, Acetaldehyde, Kidney, Butanones, Rats, Liver, Animals, Alcoholic Intoxication, Spleen
Male, Muscles, Myocardium, Acetoin, Brain, Acetaldehyde, Kidney, Butanones, Rats, Liver, Animals, Alcoholic Intoxication, Spleen
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