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Diabetes, Metabolic Syndrome and Obesity
Article
Data sources: Europe PubMed Central
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PubMed Central
Conference object . 2019
License: CC BY NC
Data sources: PubMed Central
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Diabetes, Metabolic Syndrome and Obesity
Article . 2019
Data sources: DOAJ
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Dove Medical Press
Review . 2019 . Peer-reviewed
Data sources: Dove Medical Press
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Therapeutic targets of hypercholesterolemia: HMGCR and LDLR.

descriptionPublicationkeyboard_double_arrow_right Article , Conference object , Review 01 Aug 2019 English Publisher:DoveJournal:Diabetes, metabolic syndrome and obesity : targets and therapy, volume 12 (issn: 1178-7007, Copyright policy )
Authors: Ma,Shizhan; Sun,Wenxiu; Gao,Ling; Liu,Shudong;

pmid: 31686875

pmc: PMC6709517

Therapeutic targets of hypercholesterolemia: HMGCR and LDLR.

Abstract

Cholesterol homeostasis is critical and necessary for the body's functions. Hypercholesterolemia can lead to significant clinical problems, such as cardiovascular disease (CVD). 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and low-density lipoprotein cholesterol receptor (LDLR) are major points of control in cholesterol homeostasis. We summarize the regulatory mechanisms of HMGCR and LDLR, which may provide insight for new drug design and development.

Related Organizations
Keywords

HMGCR, RC581-951, Diabetes, Metabolic Syndrome and Obesity, Cholesterol homeostasis, Specialties of internal medicine, LDLR;, Review, CVD

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 44
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
44
Top 10%
Top 10%
Top 10%
Green
gold