[A new isobenzofuranone derivative from Chaenomeles sinensis and its antibacterial activity].
Copyright policy )[A new isobenzofuranone derivative from Chaenomeles sinensis and its antibacterial activity].
A new isobenzofuranone derivative was isolated from Chaenomeles sinensis by using various chromatographic techniques,including silica gel,Sephadex LH-20,MCI-gel resin and RP-HPLC. This compound was determined as 2,2-dimethyl-5-( 2-oxopropyl)-2 H-furo[3,4-h]chromen-7( 9 H)-one( 1) by NMR,MS,IR and UV spectra,and was also evaluated for its antibacterial activity. The results showed that it showed prominent antibacterial activity with MIC90 value of( 53. 7±4. 5) mg·L-1 for methicillin resistant Staphylococcus aureus( MRSA) strain. This value is close to that of levofloxacin [with MIC90 value( 50. 2± 4. 2) mg·L-1].
- Kunming University China (People's Republic of)
Methicillin-Resistant Staphylococcus aureus, Phytochemicals, Microbial Sensitivity Tests, Rosaceae, Chromatography, High Pressure Liquid, Anti-Bacterial Agents, Benzofurans
Methicillin-Resistant Staphylococcus aureus, Phytochemicals, Microbial Sensitivity Tests, Rosaceae, Chromatography, High Pressure Liquid, Anti-Bacterial Agents, Benzofurans
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