1. In 1987 transplants, the association between the DR1 antigen and increased graft survival appears to have been lost. 2. Average preformed panel reactive antibodies, peak or current, were higher in grafts that were lost in the early posttransplant period, when compared to grafts with excellent function. Increased HLA-DR mismatches and female donors were also associated with early graft losses. 3. Recipient sex (male), HLA-DR mismatches, and donor age appeared to influence later graft losses. 4. Recipient age, HLA-B,DR and HLA-A,B,DR mismatches, and CITs were elevated in all graft loss groups.