[DFMO: an alternative therapeutic agent for human African trypanosomiasis].

J C, Breton; B, Bouteille; T, Sonan

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Article . 1989

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[DFMO: an alternative therapeutic agent for human African trypanosomiasis].

descriptionPublicationkeyboard_double_arrow_right Article 17 Jan 1989 French Journal:Bulletin de la Societe de pathologie exotique et de ses filiales, volume 81

Authors: J C, Breton; B, Bouteille; T, Sonan;

pmid: 3143490

[DFMO: an alternative therapeutic agent for human African trypanosomiasis].

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Abstract

alpha-Difluoromethyl ornithine (DFMO) irreversibly inhibits ornithine decarboxylase (ODC), an essential enzyme for the synthesis of polyamines, and results in decreased biosynthesis of putrescine and spermidine, factors necessary for cellular multiplication. Use of this chemical agent in Trypanosoma brucei brucei infected mice eradicated the parasite from circulating blood. This treatment is now being developed for use in human pathology.

Keywords

Eflornithine, Trypanosomiasis, African, Trypanosoma brucei brucei, Animals

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