[Preimplantation genetic testing for aneuploidy].

Viktoria, Holmqvist; Laura Kristine Soenderberg, Roos; Kristin Ros, Kjartansdottir; Morten, Dunø; Morten Rønn, Petersen; Christina, Hnida; Inge Søkilde, Pedersen; Anja, Ernst; Christian Liebst Frisk, Toft; Tue, Diemer; Hans Jakob, Ingerslev; Anja, Pinborg; Kristine, Løssl

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Ugeskrift for Læger

Article . 2020

Data sources: Europe PubMed Central

[Preimplantation genetic testing for aneuploidy].

descriptionPublicationkeyboard_double_arrow_right Article 06 Apr 2020Journal:Ugeskrift for laeger, volume 181 (issn: 1603-6824,

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Authors: Viktoria, Holmqvist; Laura Kristine Soenderberg, Roos; Kristin Ros, Kjartansdottir; Morten, Dunø; Morten Rønn, Petersen; Christina, Hnida; Inge Søkilde, Pedersen; +6 Authors

pmid: 31124451

[Preimplantation genetic testing for aneuploidy].

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Abstract

This review summarises the current knowledge on preimplantation genetic testing for aneuploidy (PGT-A). Selection and transfer of euploid embryos aim to improve live birth rate (LBR) per embryo transfer, but fluorescence in situ hybridisation-based PGT-A and biopsy of cleavage stage embryos in the 2000s was a disappointment, as studies revealed a reduced LBR. Today, PGT-A includes comprehensive chromosome screening primarily of blastocyst biopsies. The benefit of PGT-A is highly debated: some suggest improved treatment outcome, while others claim, that the procedure is not cost-effective.

Keywords

Pregnancy Rate, Pregnancy, Humans, Female, Fertilization in Vitro, Genetic Testing, Aneuploidy, Preimplantation Diagnosis

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