Management of uncomplicated malaria. Plasmodium falciparum malaria is a potentially severe imported tropical infection that should be systematically suspected in patients with fever returning from an endemic region, mainly sub-Saharan Africa. The diagnosis is based on the thin and thick film -possibly replaced by a rapid test-, the results of which must be reported within two hours. The recommendations for care were updated in 2017. The main advance is the positioning of artemisinin derivative- based combinations as first-line, given their rapidity of action and their effectiveness. Management is most often hospital based but criteria have been established for outpatient care provided that the close clinical and biological follow-up recommended at day 3, 7 and 28 is respected.