Work-related musculoskeletal disorders. Upper-limb musculoskeletal disorders are painful conditions related to the overuse of periarticular soft tissues. The main musculoskeletal disorders are rotator cuff tendinopathy, epicondylalgia, carpal tunnel syndrome and non-specific pain. Musculoskeletal disorders affect millions of European workers and represent the first problem of health at work in the European Union. They testify to the intensification of working conditions affecting a growing number of workers in the industry and services sectors. Their impact in terms of pain and disruption of career, but also economic costs, make them a priority of health at work. They are multifactorial disorders associated with individual and occupational (biomechanical, psychosocial and factors related to work organization) risk factors. Prevention requires a global and integrated approach focusing on the reduction of the exposure to working constraints, early diagnosis and management and, if necessary, an intervention of stay at work.