Detection of leprosy antigenuria through DOT-ELISA.

Fifty-five samples of urine from different grades of leprosy patients and normal persons were processed for detection of PGL-1 antigen through DOT-ELISA on nitrocellulose paper strips using anti-human IgG horse raddish peroxidaseconjugate. About 66.6% of the paucibacillary and 100% of the multibacillary leprosy cases were detectable through this technique on the basis of differential colour development on the strips. Possibility of its use in the field conditions has been discussed.

Related Organizations

Central Drug Research Institute
India

Keywords

Leprosy, Lepromatous, Mycobacterium leprae, Antigens, Bacterial, Humans, Enzyme-Linked Immunosorbent Assay, Glycolipids

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