Total joint replacement is used for treating osteoarthritis of the trapeziometacarpal joint. The prosthesis is a ball and socket design resembling a total hip prosthesis and with the same risk of head luxation. To reduce this risk, dual mobility articulations have also been introduced in prosthesis of the thumb, and this is a case report of luxation of the polyethylene liner in a dual mobility prosthesis, illustrating that introducing new designs in prosthesis for the basal joint of the thumb may lead to similar complications as are seen in the hip joint.