Plasmid "curing" by some recently synthetized 4-quinolone compounds.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1988 Italy English Publisher:ESIFT Srl:Casella Postale 147, I 50018 Scandicci Fi Italy:011 39 055 4271516, EMAIL: mary@jchemother.it, Fax: 011 39 055 4271280Journal:Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, volume 7 (issn: 0392-906X,

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Authors: SELAN, Laura; SCAZZOCCHIO, Francesca; B. Oliva; S. Schippa; N. Allocati; RENZINI, Giulio;

pmid: 3066515

handle: 11564/107897 , 11573/495587

Plasmid "curing" by some recently synthetized 4-quinolone compounds.

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Abstract

Nalidixic acid and two recently synthetized 4-quinolones eliminated F'lac and R-plasmids from E. coli at concentrations of one half or one quarter of the minimum inhibitory concentration (MIC). Two of the three plasmids tested were cured by all derivatives, although with different frequencies. Pefloxacin was the most effective compound compared with the other quinolones and nalidixic acid the least active.

Country

Italy

Related Organizations

Sapienza University of Rome
Italy
University of Chieti-Pescara
Italy

Keywords

Nalidixic Acid, Ofloxacin, Escherichia coli, -, Microbial Sensitivity Tests, Pefloxacin, Plasmids

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