Femoral shaft fractures after completion of growth predominantly affect young people with healthy bones. The causes are mostly high-velocity traffic accidents, crushing or running over mechanisms and falls from a great height. Gunshot wounds are relatively rare in Germany but have a certain importance internationally and in military medicine. Accompanying injuries in local or other regions are frequent. The predominant fracture types are transverse, wedge, segment and comminuted fractures. Spiral fractures are a sign of indirect force and are therefore frequently found in older patients with osteoporosis. Atypical fractures under or following bisphosphonate treatment are a new entity, which are typically subtrochanteric and begin on the lateral side of the bone. The characteristics of pathological fractures, femoral shaft fractures in childhood and adolescence as well as periprosthetic fractures are not dealt with in this article.