Chronic inflammation is the common pathological basis for age-associated diseases. Chronic activation of basic inflammatory sates is known to associate with aging. Changes in immune system (immunosenescence), tissue microenvironment, such as the accumulation of cell debris, and systemic changes in metabolic and hormonal signals, likely contribute to the development of chronic inflammation. Inflammaging is coined to indicate the close link between aging and inflammation. In this review we will address how age-associated changes in body promote chronic inflammation.